TABLE 2

In vitro activities of regimens against R8845 and R8846 at 96 h

RegimenMean log10 CFU/ml at 96 h ± SD (mean change from baseline inoculum [log10 CFU/ml] ± SD)b
R8845R8846
DAP5.20 ± 0.14 (−2.60 ± 0.14)10.60 ± 0.02 (+3.05 ± 0.07)
TOL-TAZ9.40 ± 0.35 (+1.56 ± 0.33)10.68 ± 0.08 (+2.84 ± 0.19)
DAP+TOL-TAZ2.60 ± 0.14 (−5.29 ± 0.11)10.19 ± 0.01 (+2.55 ± 0.13)
DAP+TOL5.40 ± 0.14 (−2.40 ± 0.14)9.95 ± 0.11 (+2.05 ± 0.11)
DAP+TAZ5.33 ± 0.21 (−2.68 ± 0.23)NA
DAP+CFZ2.00 ± 0.00 (−6.05 ± 0.00)a2.00 ± 0.00 (−6.10 ± 0.00)a
Growth control10.75 ± 0.33 (+2.91 ± 0.05)10.10 ± 0.38 (+2.37 ± 0.32)
  • a The limit of detection for the CFU counting methods is 2 CFU/ml.

  • b NA, not applicable.