TABLE 1

Comparison of characterized ceftriaxone-resistant Neisseria gonorrhoeae strains

CharacteristicFC428GU140106 (5)A8806 (8)F89 (6, 7)H041 (4)
Location, yr of isolationaJapan, 2015Japan, 2014Australia, 2013France and Spain, 2010Japan, 2009
MIC (μg/ml)
    Ceftriaxone0.50.50.51–22–4
    Azithromycin0.250.50.2511
    Spectinomycin832≤641616
MLSTb19037363736319017363
NG-MAST34356543401514074240
        porB1053385410599082594
        tbpB21101011010
Key alternations in PBP2A311V, T483SA311V, T483SA311V, T483SA501P in mosaic PBP 2 XXXIVA311V, T316P, T483Sc
  • a MLST, multilocus sequence typing; NG-MAST, N. gonorrhoeae multiantigen sequence typing.

  • b MLST ST1903 (abcZ126, adk39, aroE67, fumC157, gdh148, pdhC153, and pgm65) differs with two and three loci from ST7363 (abcZ59, adk39, aroE67, fumC78, gdh148, pdhC153, and pgm65) and ST1901 (abcZ109, adk39, aroE170, fumC111, gdh148, pdhC153, and pgm65) (differences are underlined), respectively.

  • c Key amino acid alternations causing the ceftriaxone resistance (15).