TABLE 1

MICs of S-649266 and other antibacterial agents against clinical strains with various β-lactamases

Speciesβ-LactamaseNo. of isolatesMIC range (μg/ml)
S-649266aCeftazidimeCefepimeMeropenem
Pseudomonas aeruginosaIMP-130.016 to 0.5>256256 to >256128 to >256
VIM-230.25 to 1128 to 25664 to 12832 to 256
Klebsiella pneumoniaeNDM-140.5 to 2>25632 to >25664 to 256
KPC-2 or KPC-340.06 to 0.5256 to >25664 to >25616 to 256
Escherichia coliNDM-120.5 to 1>25664 to >25616 to 32
Stenotrophomonas maltophiliaL130.125 to 0.5128 to 25664 to 128128 to 256
Acinetobacter baumanniiOXA-2350.03 to 0.5128 to >25616 to 12816 to 32
  • a Supplemented with 20 μM human apotransferrin.