TABLE 1

Characteristics of mcr-1-harboring E. coli isolates

CharacteristicE. coli isolate:Salmonella sp. strain TC-M19736
M15049M15224M17059M17056M19241M19242M19441M19736M19855
Isolation dateJuly 2012Oct. 2012Nov. 2013Nov. 2013Mar. 2015Apr. 2015July 2015Nov. 2015Jan. 2016
Diagnostic/underlying disease of patientNeurologic diseaseDiabetesAppendicitisUrinary tract infectionProstate cancerHeart failureRheumatoid arthritisSecondary peritonitis/colon cancerNAa
Isolation siteBloodUrineAbdomenBloodUrine (catheter)Urine (catheter)BoneBloodAbscess
Hospital123333456
MIC (μg/ml)b of:
    Colistin816888888816
    Polymyxin B8161688888816
Additional resistance(s)cTET, TMS, CIP, FOSAMP, FGC, NIT, MIN, TMS, CIP, FOSAMP, AMS, FGC, ESC, GEN, MIN, CIPAMP, CIPCIPAMP, AMS, FGC, ESC, TMS, GENAMP, AMS, FGC, ESC, CMP, GEN, MIN, CIPAMP, AMS, CMP, CIPAMP, AMS, FGC, ESC, GEN, MIN, CIPNone
ESBLd genesNoneNoneCTX-M-14 groupNoneNoneCTX-M-2 groupCTX-M-15 groupNoneCTX-M-14 group
  • a NA, not available.

  • b Susceptibility to colistin and polymyxin B was evaluated by agar dilution.

  • c AMP, ampicillin; AMS, ampicillin-sulbactam; FGC, first-generation cephalosporins; ESC, extended-spectrum cephalosporins; TET, tetracycline; MIN, minocycline; TMS, trimethoprim-sulfamethoxazole; CIP, ciprofloxacin; FOS, fosfomycin; NIT, nitrofurantoin; GEN, gentamicin; CMP, chloramphenicol.

  • d ESBL, extended-spectrum β-lactamase.