TABLE 2

Sterol profiles of Cryptococcus spp.

SterolSterol composition (%) with the indicated treatmenta
C. neoformans var. neoformansC. neoformans var. grubiiC. gattii
DMSOFLUCVT-1129DMSOFLUCVT-1129DMSOFLUCVT-1129
Ergosta-5,7,22,24(28)-tetraenol1.2 ± 0.35.0 ± 0.52.5 ± 1.42.1 ± 1.62.3 ± 0.31.8 ± 0.24.8 ± 1.0
Ergosta-5,8,22-trienol1.0 ± 0.03.7 ± 0.33.5 ± 0.2
Ergosterol60.6 ± 2.542.2 ± 0.711.5 ± 3.943.9 ± 4.334.1 ± 3.618.7 ± 0.649.3 ± 9.752.1 ± 5.523.2 ± 2.9
Ergosta-7,22-dienol7.4 ± 0.49.3 ± 1.110.8 ± 6.0
Fecosterol [E8,24(28)]1.0 ± 0.9
Ergosta-8-enol1.6 ± 0.43.8 ± 0.5
Ergosta-5,7-dienol3.0 ± 0.61.8 ± 0.4
Ergosta-7-enol25.3 ± 1.028.8 ± 0.530.2 ± 6.61.1 ± 0.2
Eburicone1.9 ± 0.3
Lanosterol/obtusifoliol3.7 ± 0.94.4 ± 0.21.7 ± 1.110.9 ± 2.14.9 ± 0.07.2 ± 1.86.6 ± 0.2
4-Methyl fecosterol2.5 ± 0.4
Obtusifolione35.9 ± 1.817.1 ± 1.022.1 ± 1.524.5 ± 0.620.0 ± 6.039.4 ± 2.5
Eburicol1.5 ± 0.812.8 ± 0.755.8 ± 5.76.8 ± 2.030.0 ± 2.149.1 ± 1.13.1 ± 2.513.6 ± 0.715.4 ± 1.6
4,4-Dimethyl-ergosta-8,24(28)-dienol4.0 ± 0.8
  • a Mean values from three replicates ± standard deviations are shown. FLUC, fluconazole.