TABLE 4

Pharmacokinetic and pharmacodynamic characteristics of therapy

CharacteristicaValue for patientsb
Vancomycin concn (mg/liter)
    At 4 h (T1)44 (37–49)
    At 12 h (T2)25 (21–32)
    At 24 h (T3)22 (19–28)c
    On day 226 (22–30)d
AUC0–24 (mg · h/liter)771 (644–905)
Drug clearance from 0 to 24 h (mg · h/liter)3.0 (2.1–3.8)
CG-CrCL (ml/min)94 (56–140)
uCrCl (ml/min)82 (43–157)
  • a CG-CrCL, creatinine clearance according to the Cockcroft-Gault formula; uCrCL, creatinine clearance determined from urinary elimination.

  • b Data are presented as medians (25th to 75th percentiles). A total of 107 patients were evaluated except where otherwise indicated.

  • c A total of 105 patients were evaluated.

  • d A total of 56 patients were evaluated.