TABLE 6

Sensitivity, specificity, and positive and negative predictive values of vancomycin concentrations at T3 for predicting AUC0–24/MIC ratios of ≥400 at different MICsa

Vancomycin concn (mg/liter) at T3 and predictive measureValue (%) for predicting anAUC0–24/MIC ratio of ≥400 at a MIC (mg/liter) of:
0.51.01.52.0
≥15
    Sensitivity9596100100
    Specificity100100316
    PPV1001008926
    NPV020100100
≥20
    Sensitivity78788794
    Specificity1001007537
    PPV1001009557
    NPV045088
≥25
    Sensitivity37374370
    Specificity10010010093
    PPV10010010090
    NPV022478
≥30
    Sensitivity21212444
    Specificity100100100100
    PPV100100100100
    NPV011967
  • a T3, 24 h after the initiation of therapy; AUC0–24/MIC ratio, ratio between the area under the curve of drug concentrations over the first day of therapy and the MIC.