TABLE 2

Correlation of in vitro responses of 12 P. falciparum strains to the plasmodione lead and clinically used antimalarialsa

Drug pairCorrelation of in vitro response
rsP valueSignificance
Plasmodione-chloroquine−0.083920.8004NS
Plasmodione-quinine0.32170.3085NS
Plasmodione-MDAQ−0.013990.9739NS
Plasmodione-mefloquine0.083920.8004NS
Chloroquine-quinine0.65030.0257S
Chloroquine-MDAQ0.9161<0.0001S
Quinine-MDAQ0.54550.0708NS
  • a Results are presented as nonparametric coefficients of correlation and two-tailed P values. The corresponding IC50s for plasmodione and antimalarial drugs are given in Table S3 in the supplemental material. Abbreviations: MDAQ, monodesethylamodiaquine; rs, Spearman nonparametric correlation coefficient; S, significant; NS, not significant.