TABLE 1

Patient demographics and summary of hla presence and alpha-toxin expression levels

VariableNo. (%) of samplesP value (MRSA vs MSSA)
MRSAMSSA
Asia (n = 125)Europe (n = 125)United States (n = 125)Row (n = 125)All (n = 500)Asia (n = 123)Europe (n = 125)United States (n = 125)Row (n = 125)All (n = 498)
Yr collected
    2012118 (94.4)80 (64.0)77 (61.6)82 (65.6)357 (71.4)119 (96.7)68 (54.4)74 (59.2)75 (60.0)336 (67.5)0.1918
    20137 (5.6)45 (36.0)48 (38.4)43 (34.4)143 (28.6)4 (3.3)57 (45.6)51 (40.8)50 (40.0)162 (32.5)
Facility name
    Emergency room8 (6.4)5 (4.0)2 (1.6)13 (10.4)28 (5.6)7 (5.7)3 (2.4)2 (1.6)11 (8.8)23 (4.6)0.5657
    General unspecified ICU2 (1.6)14 (11.2)6 (4.8)8 (6.4)30 (6.0)6 (4.9)12 (9.6)6 (4.8)7 (5.6)31 (6.2)0.8957
    Medicine, general67 (53.6)56 (44.8)47 (37.6)48 (38.4)218 (43.6)66 (53.7)45 (36.0)44 (35.2)39 (31.2)194 (39.0)0.1397
    Medicine, ICU25 (20.0)25 (20.0)38 (30.4)33 (26.4)121 (24.2)20 (16.3)21 (16.8)37 (29.6)35 (28.0)113 (22.7)0.6012
    Outpatient0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (0.8)0 (0.0)1 (0.2)0.4990
    Pediatric, general0 (0.0)6 (4.8)4 (3.2)3 (2.4)13 (2.6)3 (2.4)15 (12.0)2 (1.6)4 (3.2)24 (4.8)0.0673
    Pediatric, ICU3 (2.4)2 (1.6)2 (1.6)3 (2.4)10 (2.0)3 (2.4)6 (4.8)6 (4.8)7 (5.6)22 (4.4)0.0320
    Surgery, general12 (9.6)8 (6.4)6 (4.8)6 (4.8)32 (6.4)12 (9.8)8 (6.4)8 (6.4)6 (4.8)34 (6.8)0.8003
    Surgery, ICU8 (6.4)9 (7.2)20 (16.0)11 (8.8)48 (9.6)6 (4.9)15 (12.0)19 (15.2)16 (12.8)56 (11.2)0.4089
Body location
    Bronchial brushing1 (0.8)9 (7.2)4 (3.2)12 (9.6)26 (5.2)1 (0.8)13 (10.4)4 (3.2)6 (4.8)24 (4.8)0.8848
    Bronchoalveolar lavage1 (0.8)15 (12.0)21 (16.8)7 (5.6)44 (8.8)6 (4.9)16 (12.8)33 (26.4)15 (12.0)70 (14.1)0.0096
    Endotracheal aspirate6 (4.8)41 (32.8)32 (25.6)61 (48.8)140 (28.0)7 (5.7)40 (32.0)24 (19.2)61 (48.8)132 (26.5)0.6191
    Lungs0 (0.0)0 (0.0)1 (0.8)0 (0.0)1 (0.2)0 (0.0)1 (0.8)0 (0.0)2 (1.6)3 (0.6)0.3732
    Sputum117 (93.6)60 (48.0)67 (53.6)45 (36.0)289 (57.8)109 (88.6)55 (44.0)64 (51.2)41 (32.8)269 (54.0)0.2511
Gender
    Female33 (26.4)34 (27.2)45 (36.0)47 (37.6)159 (31.8)50 (40.7)60 (48.0)46 (36.8)48 (38.4)204 (41.0)0.0030
    Male82 (65.6)90 (72.0)76 (60.8)76 (60.8)324 (64.8)67 (54.5)65 (52.0)76 (60.8)76 (60.8)284 (57.0)0.0137
    Not specified10 (8.0)1 (0.8)4 (3.2)2 (1.6)17 (3.4)6 (4.9)0 (0.0)3 (2.4)1 (0.8)10 (2.0)0.2413
Hospital stay
    ≥48 h96 (76.8)66 (52.8)74 (59.2)56 (44.8)292 (58.4)82 (66.7)68 (54.4)55 (44.0)42 (33.6)247 (49.6)0.0063
    <48 h22 (17.6)31 (24.8)26 (20.8)33 (26.4)112 (22.4)37 (30.1)31 (24.8)35 (28.0)45 (36.0)148 (29.7)0.0094
    Not specified7 (5.6)28 (22.4)25 (20.0)36 (28.8)96 (19.2)4 (3.3)26 (20.8)35 (28.0)38 (30.4)103 (20.7)0.5797
Age (yr)
    Median (min, max)72 (0, 98)64 (0, 93)61 (0, 94)57 (0, 96)63 (0, 98)63 (0, 90)50 (0, 94)58 (0, 90)49 (0, 89)55 (0, 94)<0.0001
    0–204 (3.2)11 (8.8)11 (8.8)17 (13.6)43 (8.6)12 (9.8)26 (20.8)12 (9.6)25 (20.0)75 (15.1)0.0017
    21–407 (5.6)14 (11.2)12 (9.6)18 (14.4)51 (10.2)15 (12.2)27 (21.6)16 (12.8)27 (21.6)85 (17.1)0.0017
    41–6026 (20.8)31 (24.8)39 (31.2)33 (26.4)129 (25.8)30 (24.4)24 (19.2)42 (33.6)32 (25.6)128 (25.7)>0.9999
    61–8060 (48.0)50 (40.0)46 (36.8)36 (28.8)192 (38.4)41 (33.3)42 (33.6)38 (30.4)31 (24.8)152 (30.5)0.0094
    81–10028 (22.4)19 (15.2)17 (13.6)21 (16.8)85 (17.0)25 (20.3)6 (4.8)17 (13.6)10 (8.0)58 (11.6)0.0186
hla gene
    Negative6 (4.8)2 (1.6)1 (0.8)0 (0.0)9 (1.8)1 (0.8)0 (0.0)0 (0.0)0 (0.0)1 (0.2)0.0209
    Positive119 (95.2)122 (97.6)123 (98.4)124 (99.2)488 (97.6)122 (99.2)125 (100.0)125 (100.0)124 (99.2)496 (99.6)0.0123
    Did not grow0 (0.0)1 (0.8)1 (0.8)1 (0.8)3 (0.6)0 (0.0)0 (0.0)0 (0.0)1 (0.8)1 (0.2)0.6242
Hla ELISA level
    Negative44 (35.2)26 (20.8)13 (10.4)20 (16.0)103 (20.6)21 (17.1)13 (10.4)14 (11.2)16 (12.8)64 (12.9)0.0012
    Positive81 (64.8)98 (78.4)111 (88.8)104 (83.2)394 (78.8)102 (82.9)112 (89.6)111 (88.8)108 (86.4)433 (86.9)0.0007
    Positive, <1 μg/ml44 (35.2)46 (36.8)38 (30.4)39 (31.2)167 (33.4)31 (25.2)29 (23.2)33 (26.4)24 (19.2)117 (23.5)0.0006
    Positive, 1–10 μg/ml36 (28.8)42 (33.6)64 (51.2)50 (40.0)192 (38.4)50 (40.7)63 (50.4)61 (48.8)46 (36.8)220 (44.2)0.0718
    Positive, >10 μg/ml1 (0.8)10 (8.0)9 (7.2)15 (12.0)35 (7.0)21 (17.1)20 (16.0)17 (13.6)38 (30.4)96 (19.3)<0.0001
    Did not grow0 (0.0)1 (0.8)1 (0.8)1 (0.8)3 (0.6)0 (0.0)0 (0.0)0 (0.0)1 (0.8)1 (0.2)0.6242