TABLE 4

AUBC over 72 h for control, ceftazidime-avibactam alone, and ceftazidime-avibactam plus amikacin combination therapy

IsolateAUBC over 72 h (log10 · h/ml)aP value (all groups)P value (CZA vs CZA-amikacin)
ControlCZA aloneCZA-amikacin combination
P. aeruginosa
    C42-72506 ± 12394 ± 0.2139 ± 21<0.001<0.001
    C42-45500 ± 7359 ± 22288 ± 30.0010.013
    1504562 ± 34301 ± 3210 ± 8<0.0010.020
K. pneumoniae
    329b592 ± 4324 ± 23b236 ± 28<0.001<0.001
    375605 ± 2323 ± 64133 ± 110.0020.015
    352567 ± 56447 ± 46165 ± 6c<0.0010.001
  • a Data are mean ± standard deviation of results from experiments in duplicate, unless otherwise noted. AUBC, area under the bacterial growth curve; CZA, ceftazidime-avibactam.

  • b Mean ± standard deviation from four experiments with CZA alone against K. pneumoniae 329b.

  • c Mean ± standard deviation from three experiments with CZA-amikacin against K. pneumoniae 352.