TABLE 3

Activity of fusidic acid alone or combined with antistaphylococcal antibiotics against biofilms of the reference strain ATCC 25923 and 5 clinical isolates grown in microtiter plates

StrainPercentage reduction in resorufin fluorescence signal in biofilms exposed to:a
Fusidic acid aloneDaptomycinLinezolidVancomycinMoxifloxacinRifampinDoxycycline
Alone+FUSAlone+FUSAlone+FUSAlone+FUSAlone+FUSAlone+FUS
ATCC 259232352774574208635371021810
2011S027842795354156857491412169
8022442245624195737611971556220047
801244303753098233706580143811824215
8012443299956497148404976295129485464
8012444062469576638841865425953924456
  • a Antibiotics used alone were at their respective fCmax values or combined with fusidic acid (FUS) at its fCmax (see Table 2 for values). Values in bold highlight combinations that show a reduction in resorufin fluorescence at least 15% higher than that of the most active drug in the combination when used alone.