TABLE 3

CFU at 72 h for control, ceftazidime-avibactam alone, and ceftazidime-avibactam plus amikacin combination therapy

IsolateCFU at 72 h (log10/ml)aP value (all groups)P value (CZA vs CZA-amikacin)
ControlCZA aloneCZA-amikacin combination
P. aeruginosa
    C42-727.44 ± 0.216.80 ± 0.972.65 ± 1.350.0170.027
    C42-456.60 ± 0.245.61 ± 0.704.19 ± 0.340.0050.020
    15047.20 ± 0.524.36 ± 0.153.96 ± 0.010.0030.298
K. pneumoniae
    329b8.41 ± 0.145.52 ± 1.22b5.56 ± 0.500.0110.963
    3758.39 ± 0.296.04 ± 0.031.7 ± 0c<0.001<0.001
    3528.38 ± 0.236.82 ± 0.934.48 ± 0.30d0.0030.021
  • a Data are mean ± standard deviation of results from experiments in duplicate, unless otherwise noted. CZA, ceftazidime-avibactam.

  • b Mean ± standard deviation from four experiments with CZA alone against K. pneumoniae 329b.

  • c Both experiments reached the lower limit of detection (1.7 log10/ml), so the standard deviation is zero.

  • d Mean ± standard deviation of results from three experiments with CZA-amikacin against K. pneumoniae 352.