TABLE 1

Mutation information for Mab_4384 among 197 M. abscessus strains used in this study

Mutation(s) of Mab_4384No. (%) of isolates with mutation in group with the indicated MIC (mg/liter)
0.5–1 (n = 6)0.125–0.25 (n = 90)≤0.062 (n = 101)
N1T0 (0)1 (1.1)2 (2.0)
G125D, Q215R0 (0)2 (2.2)1 (1.0)
A152E0 (0)1 (1.1)1 (1.0)
A169S1 (16.7)0 (0)0 (0)
Q215R1 (16.7)4 (4.4)3 (3.0)
V31I0 (0)3 (3.3)1 (1.0)
V31I, D120N0 (0)1 (1.1)0 (0)
V5 M, H7R, E142K, A217S0 (0)1 (1.1)0 (0)
H7R, E142K1 (16.7)5 (5.6)0 (0)
W88G0 (0)1 (1.1)2 (2.0)
Deletion0 (0)47 (52.2)62 (61.4)
No mutation3 (50.0)24 (26.7)29 (28.7)