TABLE 3

Susceptibility of drug-resistant HCMV strains to artemisoneb

HCMV strainResistance mutationResistanceEC50 (μM)a
ArtemisoneGanciclovir
TB40/ENoneNone0.46 ± 0.241.62 ± 0.19
CI SN3UL54 F412SGanciclovir, cidofovir0.40 ± 0.0616.71 ± 0.08
CI TL8UL97 L595SGanciclovir0.17 ± 0.0424.22 ± 0.11
  • a EC50s in HFF were determined by a quantitative HCMV DNA assay. The results represent those from at least 3 independent experiments and are expressed as means ± standard deviations.

  • b CI, clinical isolate; UL54, HCMV DNA polymerase gene; UL97, HCMV UL97 kinase gene.