TABLE 3

Bedaquiline susceptibility testing outcomes and cross-resistance profiles between CFZ and bedaquiline against six most prevalent NTM species

SpeciesBDQ resistanceaNo. of isolates against CFZ that wereb:
ResistantSensitive
M. aviumR00
S319
M. intracellulareR22
S1120
M. kansasiiR10
S044
M. gordonaeR20
S09
M. abscessusR40
S2610
M. fortuitumR20
S256
  • a The breakpoints for bedaquiline were 1.0 μg/ml and 2.0 μg/ml for SGM and RGM, respectively. R, resistant; S, sensitive.

  • b The breakpoint for CFZ was 1.0 μg/ml.