TABLE 3

Calculation of PK parameters for NHC after a single i.p. or p.o. dose in micea

RouteDose (mg/kg)Tmax (h)Cmax (nmol/ml)AUC (0–∝) (h · nmol/ml)Vz-F (liters/kg)Cl-F (liters/h/kg)t1/2 (h)Bioavailability (%)
i.p.100.2510.59.8163.92.8NA
i.p.500.0870.46222.73.15NA
p.o.500.530.231.445.86.15.256
p.o.150131.47137.98.23.243
p.o.5000.547.2202.936.89.52.736
  • a Parameters and dose-dependent oral bioavailability of NHC were calculated by using the WinNonlin software package (Pharsight). Tmax, time to maximum concentration of drug in serum; t1/2, half-life; Vz-F, apparent volume of distribution during terminal phase after nonintravenous administration; Cl-F, apparent total clearance of the drug from plasma after administration.