TABLE 3

Activities of plazomicin and comparator aminoglycosides against phenotypes and genotypes of Enterobacteriaceae isolates and other Gram-negative species

Organism phenotype or genotypeSource of breakpoint criteria for aminoglycoside resistance (no. of isolates)a% of isolates inhibited by plazomicin at ≤4 μg/mlMIC50/MIC90 (μg/ml)
PlazomicinAmikacinGentamicinTobramycin
EnterobacteriaceaeNA (4,362)99.20.5/21/40.5/40.5/4
    Amikacin resistantCLSI (14)64.31/>128>32/>32>8/>8>8/>8
EUCAST (50)90.00.5/432/>322/>8>8/>8
    Gentamicin resistantCLSI (377)96.60.5/22/8>8/>8>8/>8
EUCAST (424)95.50.5/22/8>8/>8>8/>8
    Tobramycin resistantCLSI (292)96.90.5/24/32>8/>8>8/>8
EUCAST (423)96.50.5/24/32>8/>8>8/>8
    CRENA (97)99.00.5/116/322/>8>8/>8
        CPE (all carrying blaKPC)NA (87)98.90.25/116/324/>8>8/>8
        Carbapenemase negativeNA (26)100.00.5/14/161/>82/>8
Pseudomonas aeruginosaNA (103)71.84/162/82/80.5/1
Acinetobacter baumanniiNA (99)65.22/324/>321/>81/>8
  • a NA, not applicable.