TABLE 3

In vitro susceptibility of contemporary mold isolates to olorofim and mold active azoles presented as MIC ranges, modal MICs, and the proportion of isolates with MICs above the A. fumigatus WT-UL (olorofim) and EUCAST ECOFF (licensed comparators), respectivelya

Isolate (n)OlorofimAMBItraconazolePosaconazoleVoriconazole
MIC rangeModal MIC% or proportion >0.25 mg/literMIC rangeModal MIC% or proportion >1 mg/literMIC RangeModal MIC% or proportion >1 mg/literMIC RangeModal MIC% or proportion >0.25 mg/literMIC RangeModal MIC% or proportion >1 mg/liter
Aspergillus spp.<0.004–0.25NAb00.125–4NA2<0.125 to >16NA11<0.06 to >4NA80.25–16NA7
    A. flavus (12)<0.004–0.060.0300.5–41250.125–0.50.12500.06–0.250.12500.5–218
    A. fumigatus (235)<0.004–0.250.0600.125–10.50<0.125 to >160.258<0.06 to >40.12570.25–160.55
    A. niger (17)0.008–0.250.03/0.0600.125–0.50.2500.5 to >161410.125–0.50.25250.5–4150
    A. terreus (5)0.008–0.03NA01–4140<0.125–0.50.1250<0.06–0.250.0600.5–110
    Other Aspergillus sp. (6)0.004–0.6NA00.125 to >4NA1/60.125 to >16NA3/60.06–0.5NA2/60.25–2NA2/6
Fusarium spp. (10)0.06 to >8NA901 to >4NA504 to >16NA100>4NA1008 to >16NA100
Dermatophytes (3)0.03–0.06NA00.25–1NA0<0.125–1NA0<0.06–0.5NA1/30.125–1NA0
Mucoralesc (10)>0.5NA1000.016–1NA0<0.125 to >16NA60<0.06–4NA504 to >16NA100
  • a MICs were determined visually as per E.Def 9.3.1 protocol.

  • b NA, not applicable.

  • c One each of Absidia corymbifera, Circinella muscae, Lichtheimia ramose, and Rhizomucor miehei, two Rhizomucor pusillus, and four Rhizopus microsporus isolates.