TABLE 2

Activity of Gwt1 inhibitors versus FLC-susceptible and FLC-nonsusceptible/resistant strains of Cryptococcus

SpeciesIsolateMIC (μg/ml)
APX001AAPX2020APX2039APX2041AMBFLC
C. neoformansH990.1250.0310.0040.0310.251
C. neoformansDUMC 118.000.250.0630.0160.0630.2564
C. neoformansDUMC 158.030.250.250.0310.125132
C. neoformansMYA-45640.1250.0630.0040.0160.254
C. neoformansMYA-45650.50.250.0310.1250.1251
C. neoformansMYA-45660.250.1250.0080.0630.252
C. neoformansMYA-45670.250.0630.0160.0310.251
C. neoformans141160.1250.0310.0040.0160.254
C. neoformans764840.1250.0630.0040.0160.254
C. gattiiRSA-MW-36150.1250.0310.0040.0160.2564
C. gattiiMYA-48770.250.0630.0080.0160.254
C. gattiiMYA-40930.50.1250.0160.1250.252
C. gattiiMYA-40940.250.250.0160.0630.252
C. gattiiMYA-45600.250.0630.0080.0160.0631
C. gattiiMYA-45610.50.1250.0160.0310.254
C. gattiiMYA-45620.250.1250.0160.0310.252
C. gattiiMYA-45630.50.1250.0160.0310.1254
C. gattiiMYA-45600.250.0630.0080.0160.0631
Geometric mean0.2410.0850.0100.0340.2153.564
MIC900.50.250.0310.1250.2564