TABLE 1

Antimicrobial activity of plazomicin tested against 4,825 clinical isolates collected in 70 U.S. hospitals during 2014 to 2015

Organism or group (no. of isolates)aNo. (cumulative %) of isolates at MIC (μg/ml) of:MIC50 (μg/ml)MIC90 (μg/ml)
≤0.060.120.250.51248163264128>128
Enterobacteriaceae (4,362)25 (0.6)308 (7.6)971 (29.9)1,764 (70.3)822 (89.2)317 (96.4)121 (99.2)13 (99.5)11 (99.8)2 (99.8)3 (99.9)1 (99.9)4 (100.0)0.52
    Klebsiella pneumoniae (1,506)18 (1.2)246 (17.5)621 (58.8)580 (97.3)34 (99.5)4 (99.8)1 (99.9)0 (99.9)0 (99.9)0 (99.9)0 (99.9)1 (99.9)1 (100.0)0.250.5
    Escherichia coli (1,346)1 (0.1)6 (0.5)75 (6.1)641 (53.7)534 (93.4)81 (99.4)6 (99.9)0 (99.9)0 (99.9)0 (99.9)0 (99.9)0 (99.9)2 (100.0)0.51
    Klebsiella oxytoca (359)2 (0.6)17 (5.3)92 (30.9)214 (90.5)27 (98.1)4 (99.2)1 (99.4)0 (99.4)0 (99.4)0 (99.4)1 (99.7)0 (99.7)1 (100.0)0.50.5
    Enterobacter cloacae species complex (104)0 (0.0)14 (13.5)30 (42.3)51 (91.3)8 (99.0)1 (100.0)0.50.5
    Enterobacter aerogenes (120)2 (1.7)6 (6.7)41 (40.8)53 (85.0)16 (98.3)1 (99.2)1 (100.0)0.51
    Serratia marcescens (107)0 (0.0)1 (0.9)5 (5.6)37 (40.2)52 (88.8)9 (97.2)3 (100.0)12
    Citrobacter freundii species complex (159)0 (0.0)5 (3.1)42 (29.6)91 (86.8)18 (98.1)2 (99.4)1 (100.0)0.51
    Citrobacter koseri (145)2 (1.4)12 (9.7)63 (53.1)58 (93.1)6 (97.2)3 (99.3)1 (100.0)0.250.5
    Morganella morganii (118)0 (0.0)7 (5.9)31 (32.2)38 (64.4)31 (90.7)6 (95.8)2 (97.5)2 (99.2)1 (100.0)24
    Providencia spp. (158)0 (0.0)1 (0.6)0 (0.6)18 (12.0)27 (29.1)54 (63.3)44 (91.1)5 (94.3)8 (99.4)0 (99.4)1 (100.0)24
    Proteus mirabilis (124)0 (0.0)2 (1.6)5 (5.6)23 (24.2)72 (82.3)20 (98.4)2 (100.0)24
    Proteus vulgaris group (116)0 (0.0)9 (7.8)46 (47.4)48 (88.8)12 (99.1)0 (99.1)1 (100.0)24
Pseudomonas aeruginosa (103)0 (0.0)1 (1.0)3 (3.9)1 (4.9)3 (7.8)17 (24.3)49 (71.8)17 (88.3)7 (95.1)4 (99.0)0 (99.0)0 (99.0)1 (100.0)416
Acinetobacter spp. (95)1 (1.1)0 (1.1)7 (8.4)14 (23.2)17 (41.1)25 (67.4)7 (74.7)11 (86.3)4 (90.5)4 (94.7)1 (95.8)0 (95.8)4 (100.0)216
Coagulase-negative staphylococci (72)17 (23.6)21 (52.8)26 (88.9)8 (100.0)0.120.5
Staphylococcus aureus (69)0 (0.0)14 (20.3)51 (94.2)2 (97.1)2 (100.0)0.50.5
    MRSA (30)0 (0.0)9 (30.0)18 (90.0)2 (96.7)1 (100.0)0.50.5
Streptococcus pneumoniae (66)0 (0.0)4 (6.1)32 (54.5)30 (100.0)3264
Enterococcus spp. (58)0 (0.0)1 (1.7)8 (15.5)7 (27.6)9 (43.1)5 (51.7)8 (65.5)16 (93.1)4 (100.0)1664
  • a MRSA, methicillin-resistant S. aureus.