TABLE 1

EC50s for 8-HNT compounds against T. brucei in the presence and absence of divalent transition metalsa

Divalent cationCompound 1Compound 2Compound 3
Mean EC50 (μM) ± SDShift (fold)Mean EC50 (μM) ± SDShift (fold)Mean EC50 (μM) ± SDShift (fold)
WTPlus cationWTPlus cationWTPlus cation
CaCl20.3 ± 0.80.4 ± 0.11.11.2 ± 0.041.3 ± 0.061.00.8 ± 0.10.7 ± 0.040.9
CuCl20.3 ± 0.080.4 ± 0.0051.11.4 ± 0.071.3 ± 0.060.90.8 ± 0.050.8 ± 0.061.1
FeCl20.2 ± 0.011.8 ± 0.28.00.7 ± 0.061.6 ± 0.052.40.9 ± 0.033.5 ± 0.33.7
MgCl20.4 ± 0.010.4 ± 0.031.10.8 ± 0.050.9 ± 0.021.10.8 ± 0.050.7 ± 0.050.9
MnCl20.4 ± 0.010.4 ± 0.021.01.4 ± 0.091.2 ± 0.050.80.8 ± 0.051.01 ± 0.041.3
ZnCl20.4 ± 0.012.8 ± 0.18.00.8 ± 0.0515.6 ± 0.719.70.5 ± 0.036.3 ± 0.212.0
  • a EC50s represent the means ± standard deviations for at least 3 experiments.