TABLE 2

EUCAST E.Def 9.3.1 MICs of olorofim against contemporary prospectively collected clinical mold isolates 2016 to 2017

IsolateNo.No. of isolates at MIC (mg/liter) of:aMIC (mg/liter)b
<0.0040.0040.0080.0160.030.060.1250.250.5≥1RangeModalGMWT-UL visualWT-UL 97.5%WT-UL 99%
Aspergillus spp.
    A. flavus121182<0.004–0.060.030.0500.1250.060.06
    A. fumigatus23541112334890325<0.004–0.250.060.0370.250.250.5
        WT for azoles2134912304581275<0.004–0.250.060.0370.250.250.5
        Non-WT for azoles22233950.004–0.1250.060.0420.2524
    A. giganteus11
    A. nidulans complex11
    A. niger17166310.008–0.250.03/0.060.0520.250.250.25
    A. persii11
    A. terreus52120.008–0.030.022
    A. tubingensis2110.016–0.06
    A. turcosus (A section fumigati)11
Fusarium spp.
    F. dimerum11
    F. solani complex88>0.5>0.5
    F. proliferatum11
Dermatophytesc321
Aspergillus, Fusarium, and dermatophytes28861115386710135609<0.004 to >0.50.060.0380.250.250.5
Mucoralesd1010
In total298611153867101356019<0.004 to >0.50.060.0380.250.250.5
  • a Modal MICs are highlighted in bold. MICs were determined visually as per E.Def 9.3.1 protocol.

  • b WT-UL, wild type upper limit.

  • c One each of Microsporum canis, Trichophyton interdigitale, and Trichophyton rubrum.

  • d One each of Absidia corymbifera, Circinella muscae, Lichtheimia ramose, and Rhizomucor miehei, two Rhizomucor pusillus, and four Rhizopus microsporus isolates.