TABLE 1

Characterization of seven H. influenzae isolates with reduced carbapenem susceptibility

IsolateaRegion of sourceBiotypePatient informationMLSTbPBP3 groupcMIC (μg/ml)
AgeSexSourceAmpicillinMeropenemDoripenemImipenemBiapenem
NUBL970KanagawaII5MNose1763II20.060.2544
NUBL1767IbaragiII0FNose57III+80.12448
NUBL1771KanagawaV1MNose1764III+81448
NUBL1772KanagawaII1MNose5716141616
NUBL1775SaitamaII7FVagina1765III+21448
NUBL1777NaganoV7MNose1766III+160.120.4216
NUBL2814ChibaII5MNose1683II20.25148
  • a All isolates were nontypeable and β-lactamase negative.

  • b MLST, multilocus sequence type.

  • c PBP3 group according to amino acid mutations: II, N526K; III+, S385T, L389F, and N526K. NUBL1772 was not categorized and possessed a new insertion mutation.