TABLE 4

Binding of Bocillin FL and β-lactams to recombinant PBP3 proteins

AntimicrobialIC50 (μg/ml) ± SDP value
RdNUBL1772
Ampicillin0.14 ± 0.035.13 ± 1.480.028
Meropenem0.10 ± 0.020.15 ± 0.030.049
Doripenem0.12 ± 0.050.73 ± 0.330.035
Imipenem0.20 ± 0.153.22 ± 0.590.001
Biapenem0.25 ± 0.085.86 ± 2.580.020