TABLE 2

Comparison of enhanced sensitivities of pooled and clonally grown CG mutants

Growth; measurementaFold depletionb
CGgyrB67-5H1086-3D1696-1K12
NOV pool; NGS17.16 (2.81)1.36 (0.39)1.09 (0.13)0.64 (0.20)
NOV clonal; NGS2.37 (0.30)1.11 (0.20)1.13 (0.08)0.80 (0.05)
NOV clonal; OD6002.60 (0.09)1.19 (0.05)1.13 (0.12)0.87 (0.06)
CHL pool; NGS1.17 (0.11)1.03 (0.23)0.75 (0.12)0.92 (0.04)
CHL clonal; NGS0.88 (0.05)1.09 (0.18)1.16 (0.16)1.03 (0.04)
CHL clonal; OD6001.16 (0.12)1.45 (0.03)1.30 (0.10)1.22 (0.04)
No ATB pool/no ATB clonal; NGS1.07 (0.35)0.99 (0.38)1.27 (0.07)0.93 (0.01)
  • a ATB, antibiotic; NGS, next-generation sequencing.

  • b Means (standard deviations) of the results of two independent experiments.