TABLE 2

Tissue radioactivity concentrations following a 90 mg/kg oral dose of 14C-omadacycline in LEH ratsa

TissueTissue radioactivity concn (ng · eq/ml)
0.5 h1 h3 h7 h24 h
Adrenal cortexNM1,760521354NM
Adrenal medullaNMNMNMNMNM
BileNMNMNMNMNM
Blood97.999.512512343.6b
Bone marrow257325474492295
Bone mineralNM45.31,4601,1401,380
Brain41.440.3b47.1b67.339.9
Brown fatNMNMNMNMNM
Colon wallNM2391,6903,060NM
EpididymisNMNMNMNMNM
EsophagusNM13,60019,4004,770NM
Eye53.8NS74.1b40.316.0b
Harderian glandNM2436861,074404
Heart349330288253108
Kidney, cortex541721627481133
Kidney, medulla532722588402152
Kidney, pelvis1,580832NS43798.7
Liver1,5101,100979838292
Lung287202328179115
Lymph nodeNMNMNMNMNM
Muscle11515126714237.0b
PancreasNM479463608NM
Pituitary glandNM346219154NM
Salivary gland708746884974104
Seminal vesiclesNMNMNMNMNM
SkinNMNM330395NM
Small intestine wallNMNM7,0312,150NM
Spinal cord8.65b50.643.3b77.351.7b
Spleen1,4901,6801,140555196
Stomach, glandularNM5,9401,527NM359
Testis89.449.617110176.2b
Thymus179164322NM186
Thyroid glandNM411605729NM
Uveal tractNMNMNMNMNM
White fatNM23.5b8.89bNM45.2b
  • a NM, not measurable because tissue or body fluid was not discernible in the autoradiogram; NS, not sampled.

  • b Values below the lower limit of quantitation, not included in the PK calculation.