TABLE 5

Simulated Cmax and daily AUC for patients requiring intermittent HD at 0.75 g q12h with or without a supplemental dose

ParameterMedian (90% prediction interval) ona:
Nondialysis dayDialysis day
Without supplemental doseWith supplemental dose
Cmax, μg/ml77.2 (60.4–98.3)59.3 (49.2–72.3)89.1 (72.8–109)
Daily AUC, μg · h/ml1,189 (841.8–1,659)783.2 (608.1–998.7)1,211 (941–1,515)
  • a The infusion time was 3 h.