TABLE 4

Mean pharmacokinetic parameters of omadacycline in rat plasma after a single 5 mg/kg i.v. dose or 90 mg/kg oral dose of 14C-omadacycline

Parametera14C-Omadacycline value
5 mg/kg i.v. dose (n = 3)90 mg/kg oral dose (n = 3)
t1/2 (h)4.63.9
Tmax (h)0.0830.5
Cmax (ng/ml)1,460.047.5
AUClast (ng · h/ml)3,590.0146.0
AUC0–∞/dose ([ng · h/ml]/[mg/kg])8363.1
AUC0–∞ (ng · h/ml)4,180.0283.0
CL (ml/h/kg)1,200.0
Vss (ml/kg)6,890.0
Absorption (%)2.93
Bioavailability (%)0.226
  • a AUClast, area under the concentration/time curve at last observation; AUC0–∞/dose, area under the concentration/time curve from 0 h to infinity adjusted for dose; AUC0–∞, area under the concentration/time curve from 0 h to infinity; CL, clearance; Cmax, peak concentration of drug in plasma; Tmax, time to peak concentration of drug in plasma; t1/2, half-life; Vss, volume of distribution (steady state).