TABLE 4

Simulated Cmax and daily AUC for patients with normal or augmented renal function at adjusted dose regimens using the covariate model with CG-CLCR

ParameterMedian (90% prediction interval) for the following CG-CLCR (ml/min) and adjusted dose regimena
90 to <120, 2 g q8h120 to <150, 2 g q6h150 to 200, 2 g q6h
Cmax, μg/ml99.1 (84.4–117)95.1 (81.2–112)87.0 (72.6–102)
Daily AUC, μg · h/ml1,238 (1,007–1,535)1,450 (1,196–1,776)1,278 (1,037–1,560)
  • a With original IIV. The infusion time was 3 h.