TABLE 7

Background characteristics of subjects in the data set

Study and characteristicMean (SD)Median (range)
SAD/MAD studya (n = 54)
    Age, yr30.7 (9.7)27.5 (20–60)
    Body wt, kg63.9 (8.3)62.6 (45.1–91.0)
    MDRD-eGFR, ml/min/1.73 m2110.4 (16.5)109.5 (76–146)
    CG-CLCR, ml/min138.2 (24.5)137.5 (75–185)
    Sex, no. male/no. female51/3
    Ethnicity, no. Japanese/no. Caucasian49/5
Renal impairment study (n = 37)
    Age, yr55.0 (10.8)53.0 (27–74)
    Body wt, kg87.3 (17.6)85.2 (54.4–124.1)
    MDRD-eGFR, ml/min/1.73 m251.2 (35.2)55 (4–124)
    CG-CLCR, ml/min64.5 (40.1)68 (7–136)
    Sex, no. male/no. female24/13
    Ethnicity, no. Japanese/no. other0/37
Both studies (n = 91)
    Age, yr40.6 (15.7)36 (20–74)
    Body wt, kg73.4 (17.3)68.4 (45.1–124.1)
    MDRD-eGFR, ml/min/1.73 m286.3 (38.9)99 (4–146)
    CG-CLCR, ml/min108.3 (48.2)121 (7–185)
    Sex, no. male/no. female75/16
    Ethnicity, no. Japanese/no. other49/42
  • a SAD/MAD, single- and multiple-ascending dose.