TABLE 3

MICs of select antibiotics against B. cenocepacia K56-2 WT, MKC2 (CGesaR), MKC4 (ΔesaS), 73-14C5 (CG transposon mutant of esaR), and 86-37D12 (CG transposon mutant unrelated to esaR)

DrugaMICb
WT (no rha)MKC4 (ΔesaS) (no rha)MKC2 (CGesaR)73-14C584-37D12
No rhaRhaNo rhaRhaNo rhaRha
CHL1641164161632
TET81.50.7540.5888
CIP220.12530.25222
NOV821124288
MER3224448886464
KAN1,0001,000187.51,0002501,0001,0001,000
H2O20.18750.2343750.1406250.281250.18750.18750.18750.1875
DMSO12.512.59.37512.512.512.512.512.5
  • a CIP, ciprofloxacin; MER, meropenem.

  • b Median MICs (micrograms per milliliter, except H2O2 [millimolar] and DMSO [percent {vol/vol}]) from three independent experiments; rha, rhamnose.