TABLE 5

Excretion of parent omadacycline and total radioactivity in the intact HW ratsa

Route of excretion, time of excretionAmt excreted (% of dose)
i.v. (5 mg/kg)Oral (90 mg/kg)
RadioactivityOmadacyclineRadioactivityOmadacycline
Feces, 0–24 h61.0 ± 18.156.7117 ± 2.0
Feces, 0–168 h80.4 ± 6.3120 ± 3.984.4
Urine, 0–24 h25.1 ± 2.2024.90.237 ± 0.016ND
Urine, 0–48h30.0 ± 1.490.289 ± 0.011
Total amt recovered112 ± 5.5120 ± 3.9
  • a All data are means ± standard deviations or means. ND, not detected.