TABLE 6

Pharmacokinetic parameters of liposomal amphotericin B on the last day by dosage group

ParameterValue for dosage groupa
2.5 mg/kg (n = 4)5.0 mg/kg (n = 5)7.5 mg/kg (n = 3)10 mg/kg (n = 5)
Mean AUC0–24 (μg/ml · h) ± SD301 ± 180767 ± 1,115395 ± 216786 ± 689
Mean AUC0–∞ (μg/ml · h) ± SD327 ± 194821 ± 1,118482 ± 167857 ± 696
Mean Cmax (μg/ml) ± SD49.5 ± 31.964.1 ± 45.857.4 ± 24.083.1 ± 48.9
Mean t1/2 (h) ± SD14.3 ± 7.517.9 ± 4.821.3 ± 8.827.4 ± 23.5
Mean V (liters/kg) ± SD0.20 ± 0.160.31 ± 0.200.53 ± 0.350.63 ± 0.51
Mean CL (ml/h/kg) ± SD10 ± 613 ± 1217 ± 717 ± 11
  • a Serum samples from 8 patients in the 2.5-mg/kg dosage cohort, 8 in the 5.0-mg/kg cohort, 9 in the 7.5-mg/kg cohort, and 7 in the 10-mg/kg cohort were not available for analysis.