TABLE 2

Multivariable logistic regression analysis of factors independently associated with treatment failure with ceftaroline in the efficacy populationa

VariableOdds ratio (95% CI)Adjusted odds ratio (95% CI)
APACHE II score1.100 (1.037–1.166)1.093 (1.044–1.145)
Malignancy6.000 (1.111–32.405)3.127 (1.009–9.686)
Lower respiratory tract source2.632 (1.198–5.783)
Bone/joint source0.442 (0.153–1.274)
Ceftaroline dose
    600 mg
    400 mg3.856 (1.350–11.017)
    300 mg2.892 (0.785–10.651)
    200 mg2.314 (0.814–6.577)
  • a P = 0.574 as determined by a Hosmer-Lemeshow goodness-of-fit test and a variance inflation factor of <3 for all variables included for model entry. CI, confidence interval.