TABLE 2

P. jirovecii dihydropteroate synthase genotypes in respiratory specimens from 56 adult patients with a first episode of PCP

DHPS genotypeaNo. positive/total no. (%)
HIV infected (n = 46)Non-HIV infected (n = 10)
Wild-type
    G124/46 (52)5/10 (50)
Mutant22/46 (48)5/10 (50)
Single mutant2/22 (9)2/5 (40)
    G2 (position 165)1/22 (5)2/5 (40)
    G3 (position 171)1/22 (5)0
Double mutant
    G4 (positions 165 + 171)5/22 (23)3/5 (60)
Coinfection with wild type15/22 (68)0
    G5 (1 + 2)9/22 (41)0
    G6 (1 + 3)00
    G7 (1 + 4)6/22 (27)0
Mixed single + double mutant
     G8 (2 + 4)00
  • a Genotypes G1 to G8 were described previously (37).