TABLE 2

Common adverse events with liposomal amphotericin B by dosage groupa

Adverse eventNo. of patients with adverse event in cohort
2.5 mg/kg (n = 10)5.0 mg/kg (n = 13)7.5 mg/kg (n = 12)10 mg/kg (n = 12)
Total9121012
Abdominal pain4224
Fever3524
Chills0424
Diarrhea1443
Vomiting2216
Dyspnea4165
Cough1333
Rash0344
Hypokalemia (<3 meq/liter)4428
Hyperglycemia1215
Elevated BUN level0214
  • a There were 40 patients with 47 enrollments in this study. Two patients in the 5-mg/kg group and 3 patients in the 7.5 mg/kg-group were previously enrolled in the lower-dosage group. Two patients in the 10-mg/kg group were previously enrolled in the group with the same dosage level of 10 mg/kg.