TABLE 2

Molecular characteristics of K. pneumoniae isolates from the present studya

Patient no.Strain IDOmpK36KPCblaKPCOther resistance genesPlasmid InC
11-AIS5 promoter insKPC-3blaKPC-3blaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib,strAB, sul2, dfrA14ColpVC,Col(MG828), pBK30683 repA, repB, pNJST258N3
11-BWTAA179D→Y, 243T→M532G→T, 725C→TblaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14ColpVC,Col(MG828), pBK30683 repA, repB, pNJST258N3, L/M
11-CAA288stopAA179D→Y, 243T→M532G→T, 725C→TblaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14ColpVC,Col(MG828), pBK30683 repA, repB, pNJST258N3, L/M
22-AWTKPC-3blaKPC-3blaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14pBK30683 repB, pNJST258N3
22-BWTAA240V→G (KPC-8)716T→GblaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14pBK30683 repB, pNJST258N3
22-CIS5 ins 827 bpAA179D→Y532G→TblaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14pBK30683 repB, pNJST258N3
22-DWTAA243T→A724G→AblaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14pBK30683 repB, pNJST258N3
33-AWTKPC-3blaKPC-3blaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14pBK30683 repB, pNJST258N3
33-BWTAA179D→Y532G→TblaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14pBK30683 repB, pNJST258N3
33-CWTAA179D→Y532G→TblaTEM-1, blaSHV-11, blaOXA-9, aadA1, aac(6)-Ib, strAB, sul2, dfrA14pBK30683 repB, pNJST258N3
  • a Abbreviations: InC, incompatibility group; KPC, Klebsiella pneumoniae carbapenemase; WT, wild type. All isolates had the following features: sequence type (ST) 258; wzi allele 154; clade cps-2; OmpK35, AA89stop.