TABLE 4

Infusion-related reactions with liposomal amphotericin B by dosage group

ParameterValue for dosage group
2.5 mg/kg (n = 10)5.0 mg/kg (n = 13)7.5 mg/kg (n = 12)10 mg/kg (n = 12)
No. of patients with IRR
    Total4566
    Fever (temp ≥ 1°C)3210
    Chills/rigors0113
    Nausea0001
    Vomiting0003
    Dyspnea0042
    Chest pain2010
    Abdominal pain1001
    Facial flushing0112
    Pruritis or urticaria0101
No. of infusions148173101143
No. of IRR episodes10161621
No. of IRR episodes for which patients received treatmenta3555
No. of patients discontinuing study drug for IRRs0032
  • a The following medications were used for treatment of L-AMB-associated IRRs: acetaminophen (n = 11), diphenhydramine (n = 11), hydroxyzine (n = 1), methylprednisolone (n = 1), pethidine (n = 2), and promethazine (n = 1).