TABLE 5

Pharmacokinetic parameters of liposomal amphotericin B in pediatric patients on day 1 by dosage group

ParameterValue for dosage groupb
2.5 mg/kg (n = 10)5.0 mg/kg (n = 13)7.5 mg/kg (n = 8)a10 mg/kg (n = 8)a
Mean AUC0–24 (μg/ml · h) ± SD54.7 ± 32.9351 ± 445134 ± 80.9430 ± 566
Mean AUC0–∞ (μg/ml · h) ± SD75.7 ± 31.9 B442 ± 551168 ± 95.0548 ± 604 B
Mean Cmax (μg/ml) ± SD15.1 ± 9.0 C46.2 ± 46.730.0 ± 20.567.9 ± 74.2 C
Mean t1/2 (h) ± SD8.8 ± 2.112.6 ± 8.413.5 ± 8.68.7 ± 3.8
Mean V (liters/kg) ± SD0.47 ± 0.180.86 ± 0.861.22 ± 1.370.68 ± 0.90
Mean CL (ml/h/kg) ± SD38 ± 1345 ± 3860 ± 3846 ± 39
  • a Serum samples from 4 patients each in the 7.5-mg/kg and 10-mg/kg dosage cohorts were not available for analysis.

  • b B and C indicate P values of <0.05 for comparisons.