TABLE 2

MICs of 24 antimicrobials for 18 blaIMP-harboring environmental isolates recovered from nursery and farrowing barns of a single swine production systema

IsolateMIC (μg/ml)
AMCAMPAZMCFZFEPCTXFOXCPDCAZCTFCROCHLCIPGENIPMMEMNALTZPSTRSFZTXCTZCTETSXT
13-19A>32>328>161664>64>32128>8>648≤1>16≤0.5448>64>25664128≤40.25
13-19B16>32>16>16>16>64>64>328>8>644≤1≤44848>25664832>4
13-28A>32>328>161664>64>32128>8>648≤1>16≤0.5448>64>25664128≤40.25
S4-A>32>32>16>16>16>64>64>328>8>6416≤1≤4444≤4>64>256>6416>320.5
S4-B4≤8>16>16216>64168>81616≤14482≤48>256164321
S5-A8>32>16>16>16>64>64>3232>8>644≤1≤4484≤48>256>6432>32>4
S8-A888>16>16>64>64>32128>8>6416≤1≤4≤0.584≤4≤2>2566464>320.5
S8-B>32>328>1616>64>64>3264>8>648≤1≤4184≤4>64>256>6432>32≤0.12
S11>32>32>16>16864>64>3232>8>648≤1≤4≤0.544≤464>2566432>32>4
S13-A>32>328>16>16>64>64>32>128>8>648≤1≤4≤0.58464≤2>256>64>128>320.5
S13-B8168>16>16>64>64>32128>8>6416≤1≤4≤0.584≤4≤2>256>64128>320.5
S14888>16>16>64>64>3264>8>6416≤1≤4≤0.584≤4≤2>2566464>320.25
S15-A1688>1616>64>64>3264>8>6416≤1≤4≤0.584≤4≤2>2566464>320.5
S15-B>32>32>16>16>16>64>64>3216>8>6432≤1≤4444≤416>256>6416>320.5
S178168>16>16>64>64>3264>8>6416≤1≤4184≤4≤2>2566464>320.5
S188328>16432>64>3232>8644≤1≤4≤0.521≤4>64>2563232>32≤0.12
S1916168>16>16>64>64>3264>8>6416≤1≤4≤0.584≤4≤2>2566464>320.5
S23>32>322>16>16>64>64>32128>8>644≤1≤4≤0.58248>256>6464>32≤0.12
  • a Antimicrobials tested and resistance MIC cutoff values (R, in micrograms per milliliter) when determined: AMC, amoxicillin-clavulanic acid (2:1 ratio), R ≥ 32; AMP, ampicillin, R ≥ 32; AZM, azithromycin, R >16; CFZ, cefazolin, R ≥ 8; FEP, cefepime, R ≥ 32; CTX, cefotaxime, R ≥ 4; FOX, cefoxitin, R ≥ 32; CPD, cefpodoxime, R ≥ 8; CAZ, ceftazidime, R ≥ 16; CTF, ceftiofur, R ≥ 8; CRO, ceftriaxone, R ≥ 4; CHL, chloramphenicol, R ≥ 32; CIP, ciprofloxacin, R ≥ 4; GEN, gentamicin, R ≥ 16; IPM, imipenem, R ≥ 4; MEM, meropenem, R ≥ 4; NAL, nalidixic acid, R ≥ 32; TZP, piperacillin/tazobactam), R ≥ 128/4; STR, streptomycin, R ≥ 64; SFZ, sulfisoxazole, R >256; TXC, cefotaxime-clavulanic acid; TZC, ceftazidime- clavulanic acid; TET, tetracycline, R ≥ 16; SXT, trimethoprim-sulfamethoxazole, R ≥ 4/76. Isolate-antibiotic combinations that demonstrated resistance are shown in boldface.