TABLE 2

Summary of plasma and intracellular pharmacokinetic parameters

ParameterValue for:P valueb
Children (n = 30)Adults (n = 29)a
MedianRangeMedianRange
Plasma
    Cmax (μg/ml)22.717.0–29.331.917.2–42.41.421e−06**
    Tmax (days)27.813.9–28.016.013.8–28.10.21
    t1/2 (days)37.17.4–47.034.49.5–46.150.07221
    AUCd0–d29 (μg · day/ml)448304–583628213–8614.484e−07**
    AUCd0–∞ (μg · day/ml)652438–832880427–1,2065.645e−06**c
Intracellular
    Cmax (μg/ml)55.619.8–38271.540.0–1500.006168*
    Tmax (days)23.213.0–28.027.513.8–30.00.4236
    AUCd0–d29 (μg · day/ml)964393–4,5521316625–2,6670.006794
  • a One patient was excluded from the noncompartmental analyses because of insufficient data points.

  • b *, P < 0.01; **, P < 0.001 (by Mann-Whitney U test unless otherwise indicated).

  • c By Student t test.