Table 2.

Sites associated with quinolone resistance in the quinolone-resistance-determining regions of GrlB and GyrB

ProteinSpeciesTypeSequence and sites associated with quinolone resistanceaMutationSource or reference
GrlB (ParE) S. aureus Wild type VEGDSAGGSA KLGRDRKFQA ILPLRGKVIN TEKARLEDIF KNEEINTIIT
S. aureus Mutant                                              ∗ Asn470AspThis study
S. pneumoniae Mutant    ∗ Asp435Asn 31
E. coli Mutant                               ∗ Leu445His 4
GyrB S. aureus Wild type VEGDSAGGST KSGRDSRTQA ILPLRGKILN VEKARLDRIL NNNEIRQMIT
S. aureus Mutant    ∗ Asp437Asn 15
S. pneumoniae Mutant    ∗ Asp435Asn 27
E. coli Mutant    ∗ Asp426Asn 42
S. aureus Mutant                           ∗ Arg458Gln 15
E. coli Mutant                           ∗ Lys447Glu 42
S. typhimurium Mutant                                             ∗ Ser463Tyr 11
  • a Sites associated with quinolone resistance are indicated by asterisks.