Table 1.

Effects of cefotaxime and piperacillin on metabolic peak height and time to peaka

Antibiotic and concn (μg/ml)First peak ht (μV/s)Time to first peak (min)PAE (min)b
Cefotaxime
  0440 ± 40186 ± 6
  0.12508 ± 5405 ± 997 ± 15
  0.24526 ± 31392 ± 584 ± 11
  0.48398 ± 8408 ± 4101 ± 10
Piperacillin
  0482 ± 2159 ± 1
  4511 ± 7358 ± 279 ± 3
  8487 ± 31368 ± 889 ± 9
 16427 ± 6374 ± 495 ± 5
  • a Values are means ± standard errors. Data are based on duplicate experiments.

  • b PAE = (time to first peak) − (time to first peak of negative control) − (exposure time).