Table 3.

Multiple-sequence alignment for the Ω-loop region in the class A β-lactamases

Source Sequence of Ω loop, locus IVa
            *      *
B. fragilisCS30162-VIHTENDMHKNLEFCYQNWTTP-183
B. uniformisWAL-7088162-LSETEDGMHSSFEAVYRNWSTP-183
PER-1, P. aeruginosaRNL-1167-VVANEAQMHADDQVQYQNWTSM-188
B. vulgatusCLA341180-IAYTEEEMSADHNKAYSNYTSP-201
OHIO-1, E. cloacae 158-LDRWETELNEALPGDARDTTTA-179
SHV-1, K. pneumoniae 158-LDRWETELNEALPGDARDTTTP-179
LEN-1, K. pneumoniaeLEN-1158-LDRWETALNEALPGDARDTTTP-179
TEM-1, E. coli 160-LDRWEPELNEAIPNDERDTTMP-181
P. mirabilisGN179165-LDRWEPELNEAVPGDKRDTTTP-186
PSE-4, P. aeruginosaDalgleish157-LDRIEPDLNEGKLGDLRDTTTP-178
R. capsulatusSP108166-LDRIEPKLNDFASGDERDTTSP-187
NMC,E. cloacaeNOR-1164-LDRWELDLNTAIPGDERDTSTP-185
Sme-1, S. marcescensS6166-LDRWELELNTAIPGDKRDTSTP-187
OXY-2, K. oxytocaD488164-LDRTEPTLNTAIPGDERDTSTP-185
K. oxytocaE23004/SL781/SL7811165-LDRTEPALNSAIPGDKRDTTTP-186
S. typhimuriumCAS-5165-LDRTEPTLNTAIPGDPRDTTTP-186
MEN-1, E. coliMEN137-LDRTEPTLNTAIPGDPRDTTSP-158
S. fonticolaCUV141-LDRTEPTLNTAIPGDKRDTTSP-162
C. diversusULA27168-LDRKEPELNTAIPGDERDTTCP-189
P. vulgaris5E78-1167-LDRKEPELNTAIHGDPRDTTSP-188
B. cepacia249175-LDRWETELNTALPGDLRDTTTP-196
Y. enterocoliticaserotype O:3/Y-56167-LDRWEPDLNTARPNDPRDTTTP-188
M. tuberculosisH37RV178-LDAEEPELNRDPPGDERDTTTP-199
S. clavuligerus NRRL 3585186-MDQYEPELNHDPPHDPRDTTTP-207
III,B. cereus569/H185-SERFEPELNEVNPGETHDTSTP-206
B. licheniformis749/C176-PERFEPELNEVNPGETQDTSTA-197
I,B. mycoidesNI10R179-SDRFETELNEAIPGDIRDTSTA-200
I,B. cereus569/H/9181-SNRFETELNEAIPGDIRDTSTA-202
I,B. cereus5/B179-SDRFETELNEAIPGDIRDTSTA-200
B. subtilis168/6GM179-AKRFETDLNSAIPGDIRDTSTA-200
2,S. cacaoiDSM40057186-MERVEPFLSRWEPGSKRDTSTP-207
S. badiusDSM40139184-MDREEPELSRWVPGEKRDTSTP-205
Actinomadura sp. strain R39176-ADRIETELNEVPPGETRDTSTP-197
N. lactamduransLC411175-ADRWEPELNSAVPGDVRDTSTP-196
S. cacaoi KCC S0352194-MDRYEQELGSAVPGDPRDTSTP-215
ROB-1, H. influenzaeF990/LNPB51/A1176-TNRLEPDLNQAKPNDIRDTSTP-197
S. fradiaeDSM40063178-LDRWEPELNSAEPGRVTDTTSP-199
S. lavendulaeDSM2014178-LDRWEPELNSAEPGRLTDTTTP-199
S. albusG187-LDRWEPELNSAEPGRVTDTTSP-208
S. lavendulaeKCCS0263176-LDRWEPELNSAEPDRVTDVTTP-197
S. aureofaciens 183-LDRWEPALNSAEPDRVTDTTSP-204
S. cellulosaeKCCS0127180-LDRWEPELNSGEPDRRTDTTSP-201
M. fortuitum 167-LDRWEVELNSAIPGDPRDTSTA-188
S. aureus PC1/SK456/ NCTC 9789153-PVRYEIELNYYSPKSKKDTSTP-174
BRO-1, M. catarrhalis ATCC 53879184-LANNEPLLNRSHYGETSDTAKP-205
  • a The numbering system for the sequences is according to the sequence for each protein as deposited in the GenBank or SWISS-PROT data banks. Positions corresponding to Glu-166 and Asn-170, respectively, are marked with asterisks.