Table 1.

Enzymes used in the multiple-sequence analysis and their sources

β-Lactamase or PBP class and sourceAccession no.Data bank
Class D β-lactamasesa
 OXA-18, Pseudomonas aeruginosa Mus U85514 GenBank
 OXA-9, Klebsiella pneumoniae P22070 SWISS-PROT
Aeromonas sobria AER 14 X80276 GenBank
 OXA-1, Escherichia coli K10-35 P13661 SWISS-PROT
 OXA-7, E. coli 7181 P35695 SWISS-PROT
 OXA-11, P. aeruginosa ABD Q06778 SWISS-PROT
 OXA-5, P. aeruginosa 76072601 Q00982 SWISS-PROT
 LCR-1, P. aeruginosa 2293E Q00983 SWISS-PROT
 OXA-2, Salmonella typhimurium type 1A P05191 SWISS-PROT
High-molecular-weight class C PBPsb
 BLAR1, Bacillus licheniformis749/C P12287 SWISS-PROT
 BLAR1, Staphylococcus aureus NCTC 9789 P18357 SWISS-PROT
 MECR1,Staphylococcus epidermidis WT55/N315 P26597 SWISS-PROT
Low-molecular-weight class A PBPsb
 PBP 5, P. aeruginosa PAO1 P72161 SWISS-PROT
 PBP 7, E. coli K-12/BHB2600 P33364 SWISS-PROT
 PBP 7, Haemophilus influenzaeRD/KW20 P44664 SWISS-PROT
E. coliK-12/BHB2600 P33013 SWISS-PROT
S. typhimuriumLT2 P37604; P37605 SWISS-PROT
 PBP 5, E. coliK-12 P04287 SWISS-PROT
 PBP 6, E. coliK-12 P08506; P77287 SWISS-PROT
 PBP 5, H. influenzae RD/KW20 P44466 SWISS-PROT
Bacillus stearothermophilus ATCC 15952 Q05523 SWISS-PROT
 PBP 5,Bacillus subtilis 168 P08750 SWISS-PROT
Streptococcus pyogenes M49 X89237 GenBank
B. subtilis MB24 P38422 SWISS-PROT
 PBP 5*,B. subtilis 168/Marburg P35150 SWISS-PROT
Streptomyces sp. strain K15 P39042 SWISS-PROT
Mycobacterium tuberculosis H37Rv Z74024 GenBank
 PBP 4, S. aureus NCTC 8325 X91786 GenBank
High-molecular-weight class A PBPsb
 PBPA, Mycobacterium leprae L39923 GenBank
M. tuberculosis H37Rv Z80775 GenBank
 PBP 1a, M. leprae S82044 GenBank
 PBP 1b, E. coli K-12/W3110 P02919; P75664 SWISS-PROT
 PBP 1b,H. influenzae RD/KW20 P45345 SWISS-PROT
 PBP 1a,Streptococcus pneumoniae 2039 X67870 GenBank
 PBP 1a, S. pneumoniae45607/63915/R6X Q04707 SWISS-PROT
 PBP 1a,Streptococcus oralis Q00573 SWISS-PROT
 PBP 1a/1b,B. subtilis 168 P39793 SWISS-PROT
 PBP 2,S. aureus SRM705 X62288 GenBank
 PBP 1a, E. coli K12/MG1655 P02918; P76688 SWISS-PROT
 PBP 1a,H. influenzae RD/KW20 P31776 SWISS-PROT
 PBP 1a,P. aeruginosa PAO1 U73780 GenBank
 PBP 1,Neisseria gonorrhoeae FA19 U72876 GenBank
 PBP 1a, Synechocystis sp. strain PCC6803 D64000 GenBank
 PBP 1b,Synechocystis sp. strain PCC6803 D90913 GenBank
 PBP 1b, Synechocystis sp. strain PCC6803 D90904 GenBank
 PBP 4, B. subtilis168 P38050 SWISS-PROT
 PBP 1a, B. subtilis168 P40750 SWISS-PROT
 PBP 1c, E. coliK-12/MG1655 P76577 SWISS-PROT
High-molecular-weight class B PBPsb
 PBP 2b, Streptococcus thermophilus Sfi6 U58210 GenBank
 PBP 2b, S. pneumoniae R6 P10524 SWISS-PROT
 PBP 2b, B. subtilis 168 Q07868 SWISS-PROT
 PBP, B. subtilis 168 Q03524 SWISS-PROT
 PBP 2x, S. pneumoniae R6 P14677 SWISS-PROT
 PBP 2, Neisseria meningitidis 1DA X59628 GenBank
 PBP 2, N. gonorrhoeae LM306/CDC84-060384 P08149 SWISS-PROT
 PBP 3, E. coli K-12 P04286 SWISS-PROT
 PBP 3,H. influenzae RD/KW20 P45059 SWISS-PROT
 PBP 3a/PBP 3x, P. aeruginosa PAO1 X95517 GenBank
 PBP 3, P. aeruginosaPAO1 X84053 GenBank
 PBP,Synechocystis sp. strain PCC6803 D90903 GenBank
 PBP 2, M. tuberculosis H37Rv Z95388 GenBank
 PBP 2, M. leprae Z70722 GenBank
 PBP 2, M. tuberculosis H37Rv Z80233 GenBank
 PBP 2, E. coli K-12 P08150 SWISS-PROT
 PBP 2, H. influenzae RD/KW20 P44469 SWISS-PROT
 PBP 5,Enterococcus faecium X92687 GenBank
 PBP 5,Enterococcus hirae R40 X62280 GenBank
 PBP 5,Enterococcus faecalis X78425 GenBank
 PBP 2, B. subtilis 168TrpC2 D38161 GenBank
 PBP 2′, S. aureus P07944 SWISS-PROT
 PBP 2′, S. aureus X52593 GenBank
Streptomyces clavuligerusNRRL 3585 U56256 GenBank
Class A β-lactamasesa
Bacteroides fragilisCS30 L13472 GenBank
Bacteroides uniformisWAL-7088 P30898 SWISS-PROT
 PER-1, P. aeruginosaRNL-1 P37321 SWISS-PROT
Bacteroides vulgatusCLA341 P30899 SWISS-PROT
 OHIO-1, Enterobacter cloacae P18251 SWISS-PROT
 SHV-1, K. pneumoniae P23982 SWISS-PROT
 LEN-1, K. pneumoniae LEN-1 P05192 SWISS-PROT
 TEM-1, E. coli P00810 SWISS-PROT
Proteus mirabilisGN179 P30897 SWISS-PROT
 PSE-4, P. aeruginosaDalgleish P16897 SWISS-PROT
Rhodopseudomonas capsulatus SP108 P14171 SWISS-PROT
 NMC, E. cloacae NOR-1 P52663 SWISS-PROT
 Sme-1, Serratia marcescens S6 P52682 SWISS-PROT
 OXY-2,Klebsiella oxytoca D488 P23954 SWISS-PROT
K. oxytoca E23004/SL781/SL7811 P22391 SWISS-PROT
S. typhimurium CAS-5 X92507 GenBank
 MEN-1,E. coli MEN P28585 SWISS-PROT
Serratia fonticola CUV P80545 SWISS-PROT
Citrobacter diversus ULA27 P22390 SWISS-PROT
Proteus vulgaris 5E78-1 P52664 SWISS-PROT
Burkholderia cepacia 249 U85041 GenBank
Yersinia enterocolitica serotype O:3/Y-56 Q01166 SWISS-PROT
M. tuberculosis H37RV Q10670 SWISS-PROT
S. clavuligerus NRRL 3585 Z54190 GenBank
 III, Bacillus cereus 569/H P06548 SWISS-PROT
B. licheniformis 749/C P00808 SWISS-PROT
 I, Bacillus mycoides NI10R P28018 SWISS-PROT
 I, B. cereus 569/H/9 P00809 SWISS-PROT
 I,B. cereus 5/B P10424 SWISS-PROT
B. subtilis 168/6GM P39824 SWISS-PROT
 2,Streptomyces cacaoi DSM40057 P14560 SWISS-PROT
Streptomyces badius DSM40139 P35391 SWISS-PROT
Actinomadura sp. strain R39 X53650 GenBank
Nocardia lactamdurans LC411 Q06316 SWISS-PROT
S. cacaoi KCC S0352 Q03680 SWISS-PROT
 ROB-1, H. influenzae F990/LNPB51/ serotype A1 P33949 SWISS-PROT
Streptomyces fradiaeDSM40063 P35392 SWISS-PROT
Streptomyces lavendulae DSM2014 P35393 SWISS-PROT
Streptomyces albus G P14559 SWISS-PROT
S. lavendulae KCCS0263 D12693 GenBank
Streptomyces aureofaciens P10509 SWISS-PROT
Streptomyces cellulosaeKCCS0127 Q06650 SWISS-PROT
Mycobacterium fortuitum L25634 GenBank
S. aureusPC1/SK456/NCTC9789 P00807 SWISS-PROT
 BRO-1,Moraxella catarrhalis ATCC 53879 Z54181 GenBank;
Q59514 SWISS-PROT
Low-molecular-weight class C PBPsb
 PBP 4, E. coliK-12/MG1655 P24228 SWISS-PROT
 PBP 4, H. influenzae RD/KW20 P45161 SWISS-PROT
 PBP 4,Actinomadura sp. R39 P39045 SWISS-PROT
B. subtilis 168 P39844 SWISS-PROT
 PBP 4,Synechocystis sp. PCC6803 D64002 GenBank
 PBP 4,M. tuberculosis H37Rv Z95436 GenBank
Zinc-dependent dd-peptidase (PBP), zinc-dependent PBP, S. albusG/Solvifaciens P00733 SWISS-PROT
Class C β-lactamasea
Citrobacter freundiiOS60/GN346 P05193 SWISS-PROT
E. coli K-12/MG1655 P00811 SWISS-PROT
 P99,E. cloacae P99/Q908R/MHN1 P05364 SWISS-PROT
Y. enterocolitica IP97/serotype O:5B P45460 SWISS-PROT
Morganella morganiiSLM01 Y10283 GenBank
A. sobria163a X80277 GenBank
 FOX-3, K. oxytoca1731 Y11068 GenBank
K. pneumoniaeNU2936 D13304 GenBank
P. aeruginosaPAO1 P24735 SWISS-PROT
S. marcescensSR50 P18539 SWISS-PROT
Psychrobacter immobilisA5 X83586 GenBank
Low-molecular-weight class B PBPsb
M. tuberculosisH37Rv Z84725 GenBank
M. tuberculosisH37Rv Z84498 GenBank
Streptomyces sp. strain R61 P15555 SWISS-PROT
 PBP 4, M. tuberculosisH37Rv Z81360 GenBank
N. lactamdurans LC411, PBP4 Q06317 SWISS-PROT
 PBP 4, Synechocystis sp. strain PCC6803 D90913 GenBank
 PBP 4*, B. subtilis W168 P32959 SWISS-PROT
 PBP 4*, E. coli K12/MG1655 AE000330; U00096 GenBank
Class B β-lactamasea
 II, B. cereus569/H P04190 SWISS-PROT
 II, Bacillus sp. 170 P10425 SWISS-PROT
 II, B. cereus5/B/6 P14488 SWISS-PROT
Chryseobacterium meningosepticum CCUG4310 X96858 GenBank
 IMP-1,S. marcescens AK9373/TN9106 P52699 SWISS-PROT
B. fragilis TAL3636/TAL2480 P25910 SWISS-PROT
Aeromonas hydrophila AE036 P26918 SWISS-PROT
 L1, Xanthomonas maltophilia IID 1275 P52700 SWISS-PROT
Monofunctional transglycosylases
E. coliK-12/MG1655 P46022 SWISS-PROT
K. pneumoniaeM5A1 Q48465 SWISS-PROT
H. influenzaeRD/KW20 P44890 SWISS-PROT
  • a For β-lactamases classifications, consult Bush et al. (4).

  • b For PBP classifications, consult Ghuysen (16).