Table 2.

Effects of different exposures of piperacillin on PAEa

Length of exposure (min)Time (min) to first peakTime (min) to second peakTime of PAE (min) from first peakbTime of PAE (min) from second peakbTime of PAE (min) from recoveryc
0202 ± 2280 ± 0
120414 ± 8496 ± 492 ± 1096 ± 4100 ± 2
240616 ± 12710 ± 0174 ± 14190 ± 0190 ± 4
360760 ± 16836 ± 6198 ± 18196 ± 6198 ± 4
480918 ± 16990 ± 14236 ± 18230 ± 14200 ± 18
7201,200 ± 181,290 ± 10278 ± 20290 ± 10288 ± 12
9601,530 ± 161,584 ± 14368 ± 18344 ± 14374 ± 18
1,4402,084 ± 402,140 ± 40442 ± 42420 ± 40472 ± 28
  • a Values are means ± standard errors. Data are based on duplicate experiments.

  • b PAE was derived from the time to each metabolic peak minus the time to the corresponding peak for the negative control (202 or 280 min) minus the time of each exposure to 32 μg of piperacillin per ml.

  • c Based on graphically displayed data, estimate of time to resumption of increasing metabolism after removal of antibiotic.