Table 6.

Effects of grlA, grlB, andgyrA mutations on the activities of selected quinolones

StrainGenotypeMIC (μg/ml) of:
CiprofloxacinNorfloxacinDU-6859aSparfloxacinNalidixic acidOxolinic acidNovobiocin
RN42200.51.00.03120.1264.02.00.16
BF2 nov(gyrB142)0.51.0NDa ND64.02.040.0
EN5 nov (gyrB142)gyrA 0.51.00.06250.12256.04.040.0
EN22 grlB543 216.00.06250.1264.04.00.08
EN20 grlA542 216.00.06250.1264.04.00.16
EN14 nov (gyrB142) grlB543 gyrA 48.00.1252.0128.08.010.0
EN8 nov (gyrB142) grlA542 gyrA 3264.00.516.0256.0128.040.0
  • a ND, not determined.