Table 1.

Comparative in vitro activities of triazoles and AMB

Organism (no. of isolates)MIC (μg/ml)
BMSITRFLUAMB
Range50%90%Range50%90%Range50%90%Range50%90%
Candida albicans(34)0.002–0.50.0080.030.008–0.250.030.130.25–160.510.25–10.50.5
Candida tropicalis(34)0.008–>160.12>160.03–>160.12>16≤0.13–>641>64≤0.03–10.250.5
Candida krusei(16)0.13–0.50.50.50.25–10.518–>6432640.5–111
Candida parapsilosis(11)≤0.008–0.250.030.060.06–0.250.060.130.5–8120.12–0.50.250.25
Candida kefyr(9)≤0.008≤0.008–0.060.25–10.06–1
Candida stellatoidea(7)≤0.008–0.015≤0.008–0.03≤0.13–0.250.06–0.12
Candida glabrata(16)0.12–>161160.25–>161>161–>6432>640.12–10.251
Cryptococcus neoformans(32)≤0.001–0.030.0080.016≤0.001–0.060.0080.008≤0.12–812≤0.03–0.250.120.25
Trichophyton spp. (13)a ≤0.008–0.130.060.06≤0.008–0.130.030.130.25–322160.25–10.51
Malassezia furfur(8)b 0.015–0.030.06–0.251–160.25–2
Aspergillus spp. (16)c 0.06–20.2510.06–10.250.5>640.25–20.51
Pseudallescheria boydii(6)0.03–>160.5–>162–>1281–8
  • a Trichophyton spp. were represented by four strains each of T. rubrum and T. mentagrophytes, three strains of T. tonsurans, and two strains of T. verrucosum.

  • b Antimycotic testing of M. furfurwas done on SDA containing 2% olive oil, and an inoculum size of 3 × 103 CFU per spot was used. Plates were incubated at 30°C for 5 days. MIC endpoints, including those for triazoles, were the lowest drug concentrations inhibiting all (100%) growth.

  • c Aspergillus spp. were represented by six strains of A. fumigatus, five strains of A. flavus, four strains of A. niger, and one strain ofA. nidulans.