Table 4.

Antifungal activities of triazoles and AMB againstAspergillus spp.

OrganismDrugMIC (μg/ml)MFC99(μg/ml)MFC95 (μg/ml)MFC90 (μg/ml)
A. fumigatus
 SC2164BMS0.131610.5
FLU>64
ITR0.251610.5
AMB11
 A9381BMS0.131610.5
FLU>128
ITR0.1310.50.5
AMB11
A15054 BMS0.13>16>16>16
FLU>128
ITR0.13>16>168
AMB0.50.5
A25935 BMS0.131682
FLU>128
ITR0.131641
AMB11
A. flavus
A28339 BMS0.5222
FLU>128
ITR0.250.50.50.5
AMB11
A15197 BMS0.5111
FLU>128
ITR0.250.50.250.25
AMB0.50.5
A21323 BMS0.1310.50.25
FLU>16>161616
ITR0.060.50.250.25
AMB NTa
A21437 BMS0.25110.5
FLU>16>16>16>16
ITR0.50.50.250.25
AMBNT
A27718 BMS0.13110.5
FLU>16>16>16>16
ITR0.130.250.250.25
AMBNT
A. niger
 SC2164BMS0.5111
FLU>128
ITR0.50.50.50.5
AMB0.250.25
A25717 BMS1>1688
FLU>128
ITR0.5>1644
AMB0.130.25
A22136 BMS0.5221
FLU>16>16>16>16
ITR0.25110.5
AMBNT
A24199 BMS0.2510.50.5
FLU>16>16>16>16
ITR0.25111
AMBNT
A. nidulans SC2385BMS0.0610.250.25
FLU128
ITR0.1310.50.25
AMB0.50.5
  • a NT, not tested.