Table 3.

Antimicrobial susceptibilities to ampicillin, amoxicillin-clavulanic acid, cefuroxime, cefaclor, and trimethoprim-sulfamethoxazole of 52 persistent H. influenzae isolates obtained from five CF patients at multiple time points during the 2-year follow-up study

PatientStrainaTime points (mo)Resultsb for:
AmpicillinAmox.-clav. acidCefuroximeCefaclorTrim.-sulfa
Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)
26661I20S26R0R0S33
4S24S22S28S24S38
8S23S23S31S24S40
11S24S24R15R0S34
12S29S20R0R0S35
13I21R19R0R0S34
16S25S22I23R0S36
18S23S21R0R0S38
19I19S20R0I17S29
20R18S20R0I18S29
21I20S23I22I18S36
22S24R19R0R0S36
24S24S23S28I18S34
2767a1I20S21S29S21S35
3S26S22S30I18R0
67b1S24S21S30R0S42
3I21R0S24R0S21
7S28S28S38R0R0
67d7R16R16I22R0S29
10S22S24I22R0S39
2870b1I18R18S24I18S20
9R16R17S26S21S26
3077a1S23S23I23I19S33
3S23S22S27S20S30
4I21R0S24R0S28
6S26R19S25S21S33
14S30S35S34S23S38
77b1S23S23S26S20S41
3S22S21S25I19S42
4S23S24S26I18S33
77c1I20R19S25I18S33
3S29S25S29I19S31
4S23S24S25R0S30
18S22S21S29S22S32
20I20S24S29S21S34
77e1S23R13I21R0S32
6I20R19I21R0S34
16S23S23S28S21S35
19I21S21S24R0S33
20S24S26S31S21S38
21S29S27S35S21S37
22S28S28S29R0S44
24S30S30S32S22S44
77f1S28S24S28I18S33
3S24S23S25I18S34
17S23S24S28S20S32
18S24S27S30I18S34
77i3S24R18S28S20S32
21S35S31S30S24S33
4097b3S34S35S32S29S34
4S31S31S32S30R0
5S32S31S31S30R0
  • a Numbers indicate distinct H. influenzae strains, and added letters indicate MOMP variants.

  • b Suscept., susceptibility of persistentH. influenzae isolates to the tested antibiotics. S, susceptible to the antibiotic tested; I, intermediate to the antibiotic tested; R, resistant to the antibiotic tested. Inh. zone, inhibition zone for the tested antibiotic. Amox.-clav. acid, amoxicillin-clavulanic acid; trim.-sulfa, trimethoprim-sulfamethoxazole.